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tissue distribution and expression patterns of the identified proteins  (Human Protein Atlas)

 
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    Human Protein Atlas tissue distribution and expression patterns of the identified proteins
    Tissue Distribution And Expression Patterns Of The Identified Proteins, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Identification and validation of real hub genes associated with tumor grades. (A) The five common hub genes in both the <t>co-expression</t> network and <t>protein-protein</t> interaction network were regarded as real hub genes. (B) Expression levels of the five hub genes in 103 samples with different grades. (C) Expression levels of the five hub genes in the GSE56026 dataset with different grades. (D) Expression levels of the five hub genes in the GSE115810 dataset with different grades. (E) Five genes were expressed at a significantly higher in stage Ia, Ib and Ic compared with those in normal <t>tissues;</t> however, there was no significant difference in their expression among the stage Ia, Ib and Ic EC samples. (F) There was no significant difference in gene expression levels between endometrioid EC and papillary serous EC. (G) There was no correlation between gene expression levels and age of patients. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. EC, endometrial carcinoma; MCC, maximal clique centrality; MNC, maximum neighborhood component; EPC, edge percolated component; BN, bottleneck; BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B; CCNB1, cyclin B1; CDC20, cell-division cycle protein 20; DLGAP5, DLG-associated protein 5; NCAPG, non-SMC condensing I complex subunit; ns, not significant; WCGNA, weighted gene co-expression network analysis.
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    tissue expression patterns  (Human Protein Atlas)
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    tissue-specific expression patterns  (Human Protein Atlas)
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    Identification and validation of real hub genes associated with tumor grades. (A) The five common hub genes in both the <t>co-expression</t> network and <t>protein-protein</t> interaction network were regarded as real hub genes. (B) Expression levels of the five hub genes in 103 samples with different grades. (C) Expression levels of the five hub genes in the GSE56026 dataset with different grades. (D) Expression levels of the five hub genes in the GSE115810 dataset with different grades. (E) Five genes were expressed at a significantly higher in stage Ia, Ib and Ic compared with those in normal <t>tissues;</t> however, there was no significant difference in their expression among the stage Ia, Ib and Ic EC samples. (F) There was no significant difference in gene expression levels between endometrioid EC and papillary serous EC. (G) There was no correlation between gene expression levels and age of patients. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. EC, endometrial carcinoma; MCC, maximal clique centrality; MNC, maximum neighborhood component; EPC, edge percolated component; BN, bottleneck; BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B; CCNB1, cyclin B1; CDC20, cell-division cycle protein 20; DLGAP5, DLG-associated protein 5; NCAPG, non-SMC condensing I complex subunit; ns, not significant; WCGNA, weighted gene co-expression network analysis.
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    Identification and validation of real hub genes associated with tumor grades. (A) The five common hub genes in both the co-expression network and protein-protein interaction network were regarded as real hub genes. (B) Expression levels of the five hub genes in 103 samples with different grades. (C) Expression levels of the five hub genes in the GSE56026 dataset with different grades. (D) Expression levels of the five hub genes in the GSE115810 dataset with different grades. (E) Five genes were expressed at a significantly higher in stage Ia, Ib and Ic compared with those in normal tissues; however, there was no significant difference in their expression among the stage Ia, Ib and Ic EC samples. (F) There was no significant difference in gene expression levels between endometrioid EC and papillary serous EC. (G) There was no correlation between gene expression levels and age of patients. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. EC, endometrial carcinoma; MCC, maximal clique centrality; MNC, maximum neighborhood component; EPC, edge percolated component; BN, bottleneck; BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B; CCNB1, cyclin B1; CDC20, cell-division cycle protein 20; DLGAP5, DLG-associated protein 5; NCAPG, non-SMC condensing I complex subunit; ns, not significant; WCGNA, weighted gene co-expression network analysis.

    Journal: Oncology Letters

    Article Title: Identification of a five-gene signature for predicting the progression and prognosis of stage I endometrial carcinoma

    doi: 10.3892/ol.2020.11798

    Figure Lengend Snippet: Identification and validation of real hub genes associated with tumor grades. (A) The five common hub genes in both the co-expression network and protein-protein interaction network were regarded as real hub genes. (B) Expression levels of the five hub genes in 103 samples with different grades. (C) Expression levels of the five hub genes in the GSE56026 dataset with different grades. (D) Expression levels of the five hub genes in the GSE115810 dataset with different grades. (E) Five genes were expressed at a significantly higher in stage Ia, Ib and Ic compared with those in normal tissues; however, there was no significant difference in their expression among the stage Ia, Ib and Ic EC samples. (F) There was no significant difference in gene expression levels between endometrioid EC and papillary serous EC. (G) There was no correlation between gene expression levels and age of patients. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. EC, endometrial carcinoma; MCC, maximal clique centrality; MNC, maximum neighborhood component; EPC, edge percolated component; BN, bottleneck; BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B; CCNB1, cyclin B1; CDC20, cell-division cycle protein 20; DLGAP5, DLG-associated protein 5; NCAPG, non-SMC condensing I complex subunit; ns, not significant; WCGNA, weighted gene co-expression network analysis.

    Article Snippet: The Human Protein Atlas ( http://www.proteinatlas.org ) ( ) was employed to map the tissue protein expression pattern for the real hub genes.

    Techniques: Biomarker Discovery, Expressing, Gene Expression

    Validation and survival analysis of real hub genes in UCEC based on TCGA database. The mRNA expression levels of (A) BUB1B, (B) CCNB1, (C) CDC20, (D) DLGAP5 and (E) NCAPG were significantly higher in UCEC tissues compared with those in normal tissues. Kaplan-Meier plots showing the association of (F) BUB1B, (G) CCNB1, (H) CDC20, (I) DLGAP5 and (J) NCAPG expression levels with the survival of 541 patients with UCEC, with the best expression cut-off point according to the clinical data on TCGA. BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B; CCNB1, cyclin B1; CDC20, cell-division cycle protein 20; DLGAP5, DLG-associated protein 5; NCAPG, non-SMC condensing I complex subunit; UCEC, uterine corpus endometrial carcinoma; TCGA, The Cancer Genome Atlas.

    Journal: Oncology Letters

    Article Title: Identification of a five-gene signature for predicting the progression and prognosis of stage I endometrial carcinoma

    doi: 10.3892/ol.2020.11798

    Figure Lengend Snippet: Validation and survival analysis of real hub genes in UCEC based on TCGA database. The mRNA expression levels of (A) BUB1B, (B) CCNB1, (C) CDC20, (D) DLGAP5 and (E) NCAPG were significantly higher in UCEC tissues compared with those in normal tissues. Kaplan-Meier plots showing the association of (F) BUB1B, (G) CCNB1, (H) CDC20, (I) DLGAP5 and (J) NCAPG expression levels with the survival of 541 patients with UCEC, with the best expression cut-off point according to the clinical data on TCGA. BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B; CCNB1, cyclin B1; CDC20, cell-division cycle protein 20; DLGAP5, DLG-associated protein 5; NCAPG, non-SMC condensing I complex subunit; UCEC, uterine corpus endometrial carcinoma; TCGA, The Cancer Genome Atlas.

    Article Snippet: The Human Protein Atlas ( http://www.proteinatlas.org ) ( ) was employed to map the tissue protein expression pattern for the real hub genes.

    Techniques: Biomarker Discovery, Expressing

    Validation of protein expression levels of CCNB1, CDC20, DLGAP5 and NCAPG. The (A) CCNB1, (B) CDC20, (C) DLGAP5 and (D) NCAPG proteins were expressed at higher levels in EC tissues compared with those in normal tissues, as revealed by The Human Protein Atlas database ( http://www.proteinatlas.org ). CCNB1, cyclin B1; CDC20, cell-division cycle protein 20; DLGAP5, DLG-associated protein 5; NCAPG, non-SMC condensing I complex subunit; EC, endometrial carcinoma.

    Journal: Oncology Letters

    Article Title: Identification of a five-gene signature for predicting the progression and prognosis of stage I endometrial carcinoma

    doi: 10.3892/ol.2020.11798

    Figure Lengend Snippet: Validation of protein expression levels of CCNB1, CDC20, DLGAP5 and NCAPG. The (A) CCNB1, (B) CDC20, (C) DLGAP5 and (D) NCAPG proteins were expressed at higher levels in EC tissues compared with those in normal tissues, as revealed by The Human Protein Atlas database ( http://www.proteinatlas.org ). CCNB1, cyclin B1; CDC20, cell-division cycle protein 20; DLGAP5, DLG-associated protein 5; NCAPG, non-SMC condensing I complex subunit; EC, endometrial carcinoma.

    Article Snippet: The Human Protein Atlas ( http://www.proteinatlas.org ) ( ) was employed to map the tissue protein expression pattern for the real hub genes.

    Techniques: Biomarker Discovery, Expressing